The two fleurs de lys and the red border are symbols of the old historical province of Maine, which Mayenne formed together with Sarthe, but also of the current Anjou area, neighbour with Mayenne ;
The ermine, the black symbol in the middle, is very famous for representing Brittany, the strong neighbouring region of Mayenne ;
The leopard is an element showing the proximity with Normandy, and is also a part of the coat of arms of Laval, capital city of Mayenne ;
Finally, the river shape in the middle of for the river Mayenne itself, which runs across the department, and which gave its name to it.